Beneficial effects of BBE Green Tea Extract P5000

一般來說,草藥是不同化合物的複雜混合物,它們通常以協同方式發揮其全部有益作用,然而,與西方藥物相比,相對較少的草藥已經得到很好的表徵,並且在系統的臨床試驗中證明了它們的功效。這篇綜述文章重點介紹了最近關於綠茶及其兒茶素在體外、體內和離體系統中的功效、作用機制和副作用的研究。

https://pubmed.ncbi.nlm.nih.gov/18567057/



Take 1 capsule daily.
P5000

綠茶素對肝臟和腎臟中衰老介導的氧化還原失衡具有極強的保護作用。

本研究探討綠茶提取物的兒茶素成分及其對衰老小鼠肝臟和腎臟中衰老介導的氧化還原失衡的保護作用。結果表明,本研究分析的綠茶提取物中的7種兒茶素可在30 min內完全分離,綠茶提取物中兒茶素的主要成分為EGCG、EGC和ECG。在綠茶提取物的抗衰老作用方面,以 125、625 和 1250 mg/kg 的劑量補充綠茶提取物 4 周顯著緩解了衰老介導的氧化還原失衡,從顯著 ( p< 0.05) 降低血清中硫代巴比妥酸反應物質 (TBARS) 和蛋白質羰基化合物的水平,並增加血漿中的穀胱甘肽 (GSH) 和總硫醇含量。此外,肝腎蛋白羰基水平顯著降低(p < 0.05),超氧化物歧化酶(SOD)、過氧化氫酶、葡萄糖-6-磷酸脫氫酶(G6PD)、穀胱甘肽過氧化物酶(GSH-Px)和穀胱甘肽還原酶(GSH -Rd) 在肝臟和腎臟中顯著升高 ( p< 0.05)。總體而言,這些結果清楚地表明,綠茶提取物通過抑制脂質和蛋白質的氧化損傷並增加器官中抗氧化酶的活性,對小鼠肝臟和腎臟中衰老介導的氧化還原失衡具有極強的保護作用。

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751114/

This study investigates the catechin composition and protective effect of green tea extract on senescence-mediated redox imbalance in the livers and kidneys of aged mice. The results showed that the seven catechins in the green tea extract analyzed in this study could be completely separated within 30 min and the main components of catechins in green tea extract were EGCG, EGC and ECG. In terms of the anti-senescence effects of green tea extract, green tea extract supplementation at doses of 125, 625 and 1250 mg/kg for 4 weeks significantly alleviated the senescence-mediated redox imbalance, as exhibited from significantly (p < 0.05) reduced thiobarbituric acid-reactive substances (TBARS) and protein carbonyls levels in the serum, and increased glutathione (GSH) and total thiols contents in the plasma. Additionally, hepatic and renal protein carbonyls levels were significantly diminished (p < 0.05) and the activities of superoxide dismutase (SOD), catalase, glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) in the liver and kidney were remarkably elevated (p < 0.05). Overall, these results clearly show that green tea extract exhibits extremely potent protective effects against senescence-mediated redox imbalance in the livers and kidneys of mice by inhibiting oxidative damage of lipids and proteins and increasing the activities of antioxidant enzymes in organs.

2) 抗氧化 Antioxidative

https://pubmed.ncbi.nlm.nih.gov/11239828/

https://www.sciencedirect.com/science/article/abs/pii/S1532045600001927?via%3Dihub

3) 抗衰老

https://pubmed.ncbi.nlm.nih.gov/16098958/



4)抗癌 The prevention of cancer

https://onlinelibrary.wiley.com/doi/10.1002/jcb.1164

https://pubmed.ncbi.nlm.nih.gov/11500915/


一些研究表明,綠茶對肝癌細胞具有抗增殖活性,在肝癌治療的大鼠中具有降血脂活性,以及 預防肝毒性和作為乳腺癌發病後的預防劑。

5)抗心血管疾病 cardiovascular diseases

https://pubmed.ncbi.nlm.nih.gov/11795518/

https://scholar.google.com/scholar_lookup?journal=Ann+N+Y+Acad+Sci&title=A+new+function+of+green+tea:+prevention+of+lifestyle-related+diseases&author=N+Sueoka&author=M+Suganuma&author=E+Sueoka&author=S+Okabe&author=S+Matsuyama&volume=928&publication_year=2001&pages=274-280&pmid=11795518&

6)抗血管生成 Antiangiogenic

https://pubmed.ncbi.nlm.nih.gov/12163680/

7)對神經系統的保護作用 Neuroprotective

https://pubmed.ncbi.nlm.nih.gov/15350981/

https://www.sciencedirect.com/science/article/pii/S0955286304001184?via%3Dihub

https://pubmed.ncbi.nlm.nih.gov/16957869/

8)降低膽固醇的作用 Cholesterol Cleaner

https://pubmed.ncbi.nlm.nih.gov/12873714/

https://www.sciencedirect.com/science/article/abs/pii/S0955286303000548?via%3Dihub

9)抗關節炎 Antiarthritic

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855614/#B5

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16365/

10)抗病毒 Antiviral

https://pubmed.ncbi.nlm.nih.gov/12742577/

https://www.sciencedirect.com/science/article/abs/pii/S0166354202002127?via%3Dihub

11)抗炎 Anti-inflammatory

https://pubmed.ncbi.nlm.nih.gov/12682270/

12)抗菌 antibacterial

https://pubmed.ncbi.nlm.nih.gov/15155186/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415601/

https://journals.asm.org/doi/10.1128/AAC.48.6.1968-1973.2004

13) 抗白色念珠菌

https://pubmed.ncbi.nlm.nih.gov/14688042/

https://academic.oup.com/jac/article/53/2/225/850536



14) 退行性疾病有一定的保護作用 Provide some protection against degenerative diseases

https://pubmed.ncbi.nlm.nih.gov/15570050/

15) 抗癌。Fight of cancer


預防多種癌症有關,包括肺癌、結腸癌、食道癌、口腔癌、胃癌、小腸癌、腎癌、胰腺癌和乳腺癌

It has also been linked to the prevention of many types of cancer, including lung, colon, esophagus, mouth, stomach, small intestine, kidney, pancreas, and mammary glands.

https://pubmed.ncbi.nlm.nih.gov/15464031/

https://www.sciencedirect.com/science/article/abs/pii/S0014299904007320?via%3Dihub

16)降低慢性病、中風、冠心病風險

Reduce the risk of chronic disease, stroke, coronary heart disease


幾項流行病學研究和臨床試驗表明,綠茶(以及較小程度的紅茶和烏龍茶)可以降低許多慢性病的風險。這種有益效果歸因於大量多酚的存在,多酚是有效的抗氧化劑。特別是綠茶可以降低血壓,從而降低中風和冠心病的風險。一些動物研究表明,綠茶可能通過降低血糖水平和體重來預防冠心病的發展。

https://pubmed.ncbi.nlm.nih.gov/16445946/

https://www.sciencedirect.com/science/article/abs/pii/S0024320505012415?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517497/

https://pubmed.ncbi.nlm.nih.gov/15331020/

https://www.sciencedirect.com/science/article/abs/pii/S0024320505012415?via%3Dihub

17)最近的研究表明,GTP 可以預防帕金森氏症和阿爾茨海默氏症以及其他神經退行性疾 病。研究表明 GTP 在細胞培養和動物模型中具有神經保護活性,例如預防神經毒素誘導的細胞損傷


Recent studies suggested that GTPs might protect against Parkinson's and Alzheimer's diseases and other neurodegenerative diseases. Studies have demonstrated GTP neuroprotectant activity in cell cultures and animal models, such as the prevention of neurotoxin-induced cell injury


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855614/#B10

https://pubmed.ncbi.nlm.nih.gov/12875608/

https://link.springer.com/article/10.2165/00002512-200320100-00001

18) 對付白內障 Cataractogenesis

在實驗性白內障系統中,綠茶素通過保留晶狀體的抗氧化防禦系統起作用。

In an experimental cataractogenesis system, green tea acted by preserving the antioxidant defense system of the lens.


https://pubmed.ncbi.nlm.nih.gov/12297700/

https://www.karger.com/Article/Abstract/63881

19) II 型糖尿病是一種異質性疾病,涉及外周組織中的葡萄糖和脂質代謝對胰島素的生物活性的抵抗以及胰腺 β 細胞的胰島素分泌不足。

Type II diabetes is a heterogeneous disorder that involves resistance of glucose and lipid metabolism in peripheral tissues to the biological activity of insulin and inadequate insulin secretion by pancreatic β cells.


https://pubmed.ncbi.nlm.nih.gov/11815468/

https://diabetesjournals.org/diabetes/article/51/suppl_1/S109/11759/Phasic-Insulin-Release-and-Metabolic-Regulation-in

20)防止因氧化應激增加而引起的氧化損傷

To prevent the oxidative damage caused by the increase in oxidative stress.


新陳代謝過程中活性氧 (ROS) 和其他自由基 (R) 的產生是必要且正常的過程,理想情況下可通過精心設計的內源性抗氧化系統進行補償。然而,由於許多環境、生活方式和病理情況,過量的自由基會積聚,導致氧化應激。氧化應激與心血管疾病、癌症和其他慢性疾病有關,這些疾病佔當今死亡的主要部分。抗氧化劑是阻礙氧化過程從而延遲或防止氧化應激的化合物。

The generation of reactive oxygen species (ROS) and other free radicals (R) during metabolism is a necessary and normal process that ideally is compensated for by an elaborate endogenous antioxidant system. However, due to many environmental, lifestyle, and pathological situations, excess radicals can accumulate, resulting in oxidative stress. Oxidative stress has been related to cardiovascular disease, cancer, and other chronic diseases that account for a major portion of deaths today. Antioxidants are compounds that hinder the oxidative processes and thereby delay or prevent oxidative stress. This article examines the process of oxidative stress and the pathways by which it relates to many chronic diseases. We also discuss the role that endogenous and exogenous antioxidants may play in controlling oxidation and review the evidence of their roles in preventing disease.

https://pubmed.ncbi.nlm.nih.gov/15462130/

21) 對乙醇中毒細胞膜的保護作用 (防酒精中毒)

Protective effect of green tea on erythrocyte membrane of different age intoxicated with ethanol.

https://pubmed.ncbi.nlm.nih.gov/16098958/

22) 抗腫瘤 (Anti-tumor)


https://pubmed.ncbi.nlm.nih.gov/12587987/

https://pubmed.ncbi.nlm.nih.gov/17195249/

https://pubmed.ncbi.nlm.nih.gov/12046864/

https://pubmed.ncbi.nlm.nih.gov/15965275/

https://link.springer.com/article/10.1385/MO:22:2:129

23)慢性腎髒病患病機會率下降

在囓齒動物體內,老年動物的腎臟比年輕動物的腎臟受到更惡劣的氧化環境,這會破壞腎臟的抗氧化狀態並導致氧化還原失衡。他們還提出,腎臟中 SOD 和 GSH-Px 的活性在衰老過程中顯著降低。

In vivo, in rodents, the kidneys in the aged animals are subjected to a harsher oxidative environment than the young, which damages the antioxidant status of the kidneys and causes redox imbalance.

https://pubmed.ncbi.nlm.nih.gov/9641266/

https://www.sciencedirect.com/science/article/abs/pii/S0891584998000252?via%3Dihub


24)幫助清除殘餘腎臟的自由基。

It could also help the residual kidneys to scavenge free radicals with nephrectomy.

https://pubmed.ncbi.nlm.nih.gov/8695898/

https://academic.oup.com/bbb/article/60/6/1000/5948948